This program provides an overview of the structure and functions of the kidneys and details about the major structural compartments of the kidney, including the renal vasculature, glomeruli, tubules, and interstitium. These compartments are discussed at the ultrastructural and molecular levels. Additional discussion includes the functions of these compartments and how they link to structure. Further, integrated functions of the kidneys that lead to the maintenance of body homeostasis are covered.

Course Objective(s)

Upon completion of the program, the participant will be able to:

1) explain the complex course that results in normal nephron and kidney development or congenital abnormalities of the kidneys and urinary tract

2) outline the components of the nephron and how they work in concert to form urine

3) discuss the varied roles of the kidney in homeostasis and how alterations can result in a range of disorders related to volume, electrolytes, or proteinuria

4) identify new research questions to build on current understanding of kidney physiology

Content :

On Demand 

Presentations

• Overview of Kidney Development
  Norman D. Rosenblum, MD
  
• Tubule Homeostasis
  Lloyd G. Cantley, MD, FASN
  
• Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)
  Indra R. Gupta, MD
  
• Glomerular Structure and Function
  David J. Salant, MBChB, MD
  
• Abnormalities of Glomerular Structure
  Astrid Weins, MD, PhD, FASN
  
• Renal Vasculature and Hemodynamics
  Heather A. Drummond, PhD
  
• Control of Volume and Osmolality
  Joseph G. Verbalis, MD
  
• Endocrine Functions of the Kidneys
  Mitchell H. Rosner, MD, FASN
  
• Mechanisms of Hypertension and the Kidneys
  Jordana B. Cohen, MD, MS, FASN
  
• The Renal Interstitium
  Dennis G. Moledina, MD, PhD, FASN
  
• Defining Tubular Segments
  Mark A. Knepper, MD, PhD
  
• Proximal Tubule
  Melanie P. Hoenig, MD
  
• Thick Ascending Limb of the Loop of Henle
  Jeff M. Sands, MD, FASN
  
• Distal Convoluted Tubule
  Ewout J. Hoorn, MD, PhD
  
• Collecting Duct
  Nuria M. Pastor-Soler, MD, PhD, FASN

Livestream

Presentations

• Welcome and Introduction – Co-Chairs
  01:30 PM EDT – 01:35 PM EDT
  
• Emerging Technologies for Studying the Glomerular Filtration Barrier
  01:35 PM EDT – 02:00 PM EDT
  Sargis Sedrakyan, PhD
  
• Urinary Single-Cell Profiling
  02:00 PM EDT – 02:25 PM EDT
  Katalin Susztak, MD, PhD
  
• Extracellular Vesicles
  02:25 PM EDT – 02:50 PM EDT
  Uta Erdbruegger, MD
  
• Panel Discussion and Q&A
  02:50 PM EDT – 03:00 PM EDT